Chemotherapeutic agents are
commonly used as neoadjuvant for breast cancer therapy, but there is evidence
of treatment failure for most of the patients due to acquired resistance.
Cancer stem cells, a small population of cells within tumors, contribute to
cancer resistance, tumor relapse,
and metastasis, therefore breast cancer stem cells targeted therapy is a
strategic way for overcoming chemoresistance. I am exploring molecular mechanism of chemoresistance and developing an agent for circumventing chemoresistance, as well as develop an agent for breast cancer stem cell-targeted agent.