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Title : Acute Toxicity Evaluation of Temulawak (Curcuma xanthorrhiza Roxb) Hepatoprotective Supplement.
Author :

Poppy Firzani Arifin (1) apt. Irfan Muris Setiawan, S.Farm., M.Sc. (2) Dr. Purwantiningsih, S.Si., M.Si., Apt. (3) RINI BUDI ASTUTI (4) FAUZAN AZIMA (5) Raphael Aswin Susilowidodo (6) Rosalina Wisastra (7) drh. Retno Murwanti, M.P., Ph.D. (8)

Date : 0 2020
Keyword : acute toxicityCurcuma xanthorrhiza Roxb, in vivo, LD50, supplement acute toxicityCurcuma xanthorrhiza Roxb, in vivo, LD50, supplement
Abstract : This study was carried out to evaluate the acute toxicity of Temulawak (Curcuma xanthorrhiza Roxb) hepatoprotective supplement. Temulawak is a native Indonesian plant which known to have many pharmacological benefits. In vivo study was conducted in Wistar Rats by oral administration. Temulawak (Curcuma xanthorrhiza Roxb) hepatoprotective supplement was given at doses of 2000 mg/kg body weight (BW). Animals were observed for any toxic sign and symptoms during the first 24 hours especially in the first 4 hours. In the absence of animal mortality, the observation is continued for up to 14 days with periodic observations every day. At completion of study animals were sacrificed and macroscopic observation was done. No mortality and clinical signs of toxicity were found in Temulawak (Curcuma xanthorrhiza Roxb) hepatoprotective supplement administered groups. The Lethal Dose 50 (LD 50) of this hepatoprotective supplement in female and male rats belongs to the unclassified category according to Organization of Economic Cooperation and Development (OECD) guideline or at least practically non-toxic (LD50> 5000 mg/kg BW) which is equivalent to a dose of 56 000 mg (56 g) in humans (70 kg). From macroscopic observation, there were no significant abnormalities on important organs (lung, heart, liver, kidney, stomach) after the administration of this supplement at 2000 mg/kg BW. The oral LD50 of Temulawak (Curcuma xanthorrhiza Roxb) hepatoprotective supplement was greater than 5000 mg/kg BW thus it could regarded as non-toxic. Based on the results can be concluded the safety of Temulawak (Curcuma xanthorrhiza Roxb) hepatoprotective supplement in the animal tested.
Group of Knowledge : Farmakologi dan Farmasi Klinik
Original Language : English
Level : Internasional
Status :
Published
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1 2020 RJPBCS__Arifin _Daftar is.pdf
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2 2020 RJPBCS SOHO.pdf
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3 0014004LPPTXI2017.pdf
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