ACADSTAFF UGM
| Title | : | Analysis of Serum Vitamin D and Major HistocompatibilityComplex Class I-Related Chain a (Mica) Levels in Patients With Breast Carcinoma |
| Author | : |
Asvin Nurulita (1) Prof. dr. Budi Mulyono, Sp.PK.(K).,MM (2) Dr. dr. Umi Solekhah Intansari, M.Kes., Sp.PK(K) (3) |
| Date | : | 18 2020 |
| Keyword | : | Breast carcinoma, Vitamin D, MICA Breast carcinoma, Vitamin D, MICA |
| Abstract | : | Introduction: Breast carcinoma is the most deadly cancer in women worldwide, with an incidence rate of 26 cases per 100,000 women in Indonesia. Treatment and prognosis is very dependent on the stage of breast carcinoma. Vitamin D can inhibit proliferation and invasive cancer cells, induction of differentiation, apoptosis and promotion of angiogenesis. Major Histocompatibility Complex class I - related chain A (MICA) plays a role in reducing the expression of NKG2D receptors in breast carcinomas so that they can be targeted for treatment of breast carcinoma treatment. The aim of this study was to determine vitamin D and MICA levels in serum patients with non-metastatic and metastatic breast carcinoma. Method: We examined 86 samples of breast carcinoma patients (44 non-metastatic samples and 42 metastatic samples) with a range of 29 - 68 years old. Vitamin D levels were examined by the Enzyme Linked Flourescent Assay (ELFA) method while the MICA levels were examined by Enzyme Linked Immunoabsorbant Assay (ELISA). Result: There were significant differences in mean vitamin D levels in non-metastatic and metastatic breast carcinomas (29.88 ng/mlvs19.06 ng/ml; p <0.01).Serum MICA levels in patients with non-metastatic breast carcinoma were lower (333.52 pg/ml) than in metastatic breast carcinoma (333.52 pg/mlvs528.71 pg/ml; p<0.01).A negative correlation was found between vitamin D levels and MICA in both groups (Pearson correlation, p: -0.58). Conclusion: Metastatic breast carcinoma had lower vitamin D levels and higher serum MICA levels than non-metastatic breast carcinoma. |
| Group of Knowledge | : | Patologi Klinik |
| Original Language | : | English |
| Level | : | Internasional |
| Status | : |
Published
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