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CREATION
Title : Antibacterial and Antifungal Activity of Three Monosaccharide Monomyristate Derivatives
Author :

Prof. Drs. Jumina, Ph.D. (1) MUTMAINAH (2) Prof. Drs. Bambang Purwono, M.Sc., Ph.D. (3) YEHEZKIEL STEVEN KURNIAWAN (4)
Date : 14 2019
Keyword : monosaccharide; myristate; esterification; antibacterial; antifungal monosaccharide; myristate; esterification; antibacterial; antifungal
Abstract : Microbial infections remains a serious challenge in food industries due to their resistance to some of the well-known antibacterial and antifungal agents. In this work, a novel monomyristoyl ester (fructosyl monomyristate) and two other derivatives (i.e., glucosyl and galactosyl monomyristates) were successfullysynthesized from myristic acid and monosaccharides in two-step reactions. First, the myristic acid was converted to myristoyl chloride, and then the myristoyl chloride was reacted with fructose, glucose and galactose separately to produce the corresponding monosaccharide monomyristate derivatives. The structures of the synthesized products were confirmed by Fourier transform infrared (FTIR), proton and carbon nuclear magnetic resonance (1H- and 13C-NMR), and mass spectral (MS) data. The monomyristates esters were obtained in reaction yields of 45.80%–79.49%. The esters were then evaluated for their antimicrobial activity using the disc diffusion test. It was found that the esters exhibited a medium antibacterial activity against gram-positive bacteria; however, they showed a weak antibacterial activity against gram-negative bacteria. Amongst the esters, galactosyl myristate yielded the highest antibacterial activity against Salmonella typhimurium, Staphylococcus aureusand Bacillus subtilis, while glucosyl monomyristate exhibited the highest antibacterial activity only against Escherichia coli. Additionally, all products showed remarkable antifungal activity against Candida albicans. These findings demonstrate that monosaccharide monomyristate derivatives are promising for use as biocompatible antimicrobial agents in the future.
Group of Knowledge : Kimia
Original Language : English
Level : Internasional
Status :
Published
Document
No Title Document Type Action
1 2019-Molecule-mdpi __Iin.pdf
Document Type : [PAK] Full Dokumen
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2 PEER REVIEW_ Bambang Purwono 2.pdf
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3 Molecules-24-03692-v2-Published.pdf
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4 Molecules-24-03692-v2-Published.pdf
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