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Title : Association between Increased Matrix Metalloproteinase-9 (MMP-9) Levels with Hyperglycaemia Incidence in Acute Ischemic Stroke Patients
Author :

Prof. Dr. dr. Ismail Setyopranoto, Sp.S(K) (1) dr. Rusdy Ghazali Malueka, Ph.D., Sp.S(K) (2) Andre Stefanus Panggabean (3) dr. I Putu Eka Widyadharma, Sp.S (4) dr. Ahmad Hamim Sadewa, Ph.D. (5) Rusdi Lamsudin (6) Prof. Dr. dr. Samekto Wibowo, Sp.S(K)., Sp.S(K). (7)
Date : 18 2018
Keyword : Hyperglycemia; Matrix metalloproteinase-9 (MMP-9); Acute ischemic stroke Hyperglycemia; Matrix metalloproteinase-9 (MMP-9); Acute ischemic stroke
Abstract : BACKGROUND: Hyperglycemia is common in acute stroke patients. Hyperglycemia can induce the production of reactive oxygen species, causing increased activity of matrix metalloproteinase-9 (MMP-9). AIM: This study aimed to determine an association between the increased levels of MMP-9 and the incidence of hyperglycemia in acute ischemic stroke patients. METHODS: This is a case-control study. Acute ischemic stroke patients admitted to the Stroke Unit of a reference hospital in Yogyakarta, Indonesia was divided into the hyperglycemic and non-hyperglycemic group. Demographic and clinical characteristics of each subject were recorded, and blood levels of MMP-9 were measured. Seventy-one patients were recruited, 40 subjects in the hyperglycemic group and 31 subjects in the non-hyperglycemic group. RESULTS: The median levels of blood MMP-9 level in the hyperglycemic and non-hyperglycemic group were 974.37 and 748.48 ng/mL, respectively, and the difference was statistically not significant (95% CI, 191.24-2849.53; p = 0.07). When the calculated cut-off point of 600.99 ng/mL was used, the proportion of patients with higher MMP-9 levels was significantly more in the hyperglycemic group compared with the ones in the non-hyperglycemic group (82.5% and 54.8%, respectively; OR = 3.88; p = 0.011). CONCLUSION: We concluded that the proportion of patients with MMP-9 level >600.99 ng/mL was significantly higher in acute ischemic stroke patients with hyperglycemia.
Group of Knowledge : Ilmu Kedokteran Klinik
Original Language : English
Level : Internasional
Status :
Published
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1 Association Between Increased Matrix Metallyproteinase-9 (MMP-().pdf
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2 Association between Increased Matrix Metalloproteinase-9 (MMP-9) Levels with Hyperglycaemia Incidence in Acute Ischemic Stroke Patients Cek Similarity.pdf
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3 Artikel Published-Association between increased matrix metalloproteinase-9.pdf
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4 REVISI Cek Similarity-Association between increased matrix metalloproteinase-9 (MMP-9) levels with hyperglycaemia incidence in acute ischemic stroke patients.pdf
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