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Title : Beet (Beta vulgaris) Suppressed Gene Expression and Serum Fatty Acid Synthase in High Fat and Fructose-induced Rats
Author :

SALMA NADIYAH (1) Dr. Dra. Pramudji Hastuti, Apt., M.S. (2) Prof. Dr. Dra. Sunarti, M.Kes. (3)

Date : 16 2021
Keyword : Beet,Fat,Fructose,Gene Expression,Fatty acid synthase Beet,Fat,Fructose,Gene Expression,Fatty acid synthase
Abstract : BACKGROUND: The expression and activity of fatty acid synthase (FAS) enzymes determine de novo fatty acid synthesis, which can be enhanced by a high-fat and high fructose diet or inhibited by some bioactive compound diets. Beets are a great source of therapeutic compounds that have the potential to improve health and prevent disease. AIM: This study examined the effects of beets on liver FAS gene expression and FAS levels. METHODS: A total of 25 male Wistar rats divided into five groups: (1) Standard diet (n); (2) high fat and fructose diet (HFFD); (3) HFFD have given beet 6%-contained standard diet (B1); (4) HFFD have given beet 9%-contained standard diet (B2), and (5) HFFD have given beet 12%-contained standard diet (B3). The HFFD was given to rats in the 2, 3, 4, and 5 group diets for 8 weeks? and then 3, 4, and 5 groups received beet-contained standard diet for 6 weeks. At the end of the intervention, FAS levels were measured (please specify where it was measured from) using the ELISA method, liver FAS gene expression was analyzed by quantitative polymerase chain reaction, and triglyceride (TG) levels were determined by the colorimetric method. RESULTS: The beet-substituted diet significantly suppressed the hepatic FAS gene expression and decreased the serum FAS levels in rats previously given HFFD (p < 0> 0.05). Substitution of beet 9% in diet gives the best effect in hepatic FAS gene expression and the serum FAS levels. CONCLUSIONS: The diet contained beet 9% was seen as a necessary physiological dose to improve the effects of high-fat and diet fructose diet through suppressing FAS gene expression and a decreased serum FAS levels.
Group of Knowledge : Ilmu Kedokteran Dasar & Biomedis
Original Language : English
Level : Internasional
Status :
Published
Document
No Title Document Type Action
1 4_ Beet (Beta vulgaris) Suppressed Gene Expression and Serum Fatty Acid Synthase in High Fat and Fructose-induced Rats.pdf
Document Type : [PAK] Cek Similarity
[PAK] Cek Similarity View
2 SALMA BETA VULGARIS oamjms-9a-303.pdf
Document Type : [PAK] Full Dokumen
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3 Korespondensi_Beet Fatty Acid.pdf
Document Type : [PAK] Bukti Korespondensi Penulis
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