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Title : Determining the association between polymorphisms of the DAT1 and DRD4 genes with attention deficit hyperactivity disorder in children from Java Island
Author :

Dr. dr. Cempaka Thursina Srie Setyaningrum, Sp.S(K) (1) dr. Dian Kesumapramudya Nurputra, M.Sc, Ph.D, SpA (2) dr. Indra Sari Kusuma Harahap, Ph.D., Sp.S(K) (3) dr. Nur Imma Fatimah Harahap, Ph.D. (4) Nihayatus Sa’adah (5) Prof. Dr. dr. Samekto Wibowo, Sp.S(K)., Sp.S(K). (6) Prof. Dr. dr. Sri Sutarni, Sp.S(K). (7) dr. Ahmad Hamim Sadewa, Ph.D. (8) HERMAWAN HANJAYA (9) Hisahide Nishio (10)
Date : 10 2020
Keyword : Children,ADHD, DAT,DRD4,Indonesian, case-control study Children,ADHD, DAT,DRD4,Indonesian, case-control study
Abstract : Attention deficit hyperactivity disorder (ADHD) is one of the most common neurobehavioural in the children. Genetic factor is known one of the factors which contributed in ADHD development. VNTR polymorphism in 3’UTR exon 15 of DAT1 gene and exon 3 of DRD4 gene are reported to be associated in ADHD. In this study we examine the association of ADHD with VNTR polymorphism of DAT1 and DRD4 gene in Indonesian children. Sixty-five ADHD children and 70 normal children (6-13 years of age), were included in the study, we matched by age and gender. ADHD was diagnosed by DSM-IV. We performed a casecontrol study to found the association between ADHD and VNTR polymorphism of DAT1 and DRD4 genes. The 10-repeat allele of DAT1 and 2-repeat allele of DRD4 were higher in Indonesian children. Although the frequency of these allele was higher, but it was similar both in ADHD and control groups. Neither DAT1 nor DRD4 gene genotype distribution and frequency allele between both groups (p > 0.05). No association between ADHD and VNTR polymorphism of DAT1 and DRD4 genes found in Indonesian children. This data suggest that DAT1 and DRD4 do not contribute to etiology of ADHD in Indonesian children. Further studies are needed to clarify association between VNTR polymorphism of DAT1 and DRD4 genetic with ADHD of Indonesian children in larger sample size and family based study.
Group of Knowledge : Penyakit Syaraf
Original Language : English
Level : Internasional
Status :
Published
Document
No Title Document Type Action
1 Thursina_DAT DAD_ADHD.pdf
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2 bukti korespondensi jurnal nternasional.pdf
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3 Determining the association between polymorphisms of the DAT1 and DRD4 genes with attention deficit hyperactivity disorder in children from Java Island.pdf
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