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| Title | : | Dual Functional Carbonate-Hydroxyapatite Nanocomposite from Pinctada 1 Maxima and Egg-White for Bone Tissue Engineering |
| Author | : |
DIANA JULAIDY PATTY (1) Dr.Sc. Ari Dwi Nugraheni, S.Si., M.Si. (2) Prof. drg. Ika Dewi Ana, M.Kes., Ph.D. (3) Prof. Dr. Eng. Yusril Yusuf, S.Si., M.Si., M.Eng. (4) |
| Date | : | 10 2022 |
| Keyword | : | carbonate-hydroxyapatite, biopolymer in-vitro, tissue engineering, 30 biocompatible, antibacterial carbonate-hydroxyapatite, biopolymer in-vitro, tissue engineering, 30 biocompatible, antibacterial |
| Abstract | : | This study aims to design a 3D carbonate-hydroxyapatite (CHA)/sago (S) based egg white (EW) 13 microstructure with antibacterial properties to improve the performance of bone grafts for bone 14 tissue engineering. In this study, Pinctada maxima (P. maxima) shell was used as a calcium 15 (Ca) source in the CHA synthesis. The annealing temperature of CHA at 900oC, 1000oC, and 16 1100oC affected microstructural and lattice parameters, with stoichiometry 1.72-1.77, and B- 17 type CHA was identified. CHA/S with various concentrations of EW (10 and 30wt%) 18 effectively increased pore size and porosity. XRD spectra confirmed that sago and EW in CHA 19 nanocomposite stable the crystal structure. FTIR spectrum shows protein phosphorylation in 20 CHA nanocomposite due to PO4 3- ion exchange. In-vitro bioactivity of CHA-S10 (MTT assay) 21 showed increased cell viability and optical density (24h-48 h) to control. Antibacterial activity 22 of CHA-S10 and CHA/S (control) against bacteria associated with periodontal disease and 23 bone infection (Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, 24 Fusobacterium nucleatum [gram negative], and Staphylococcus aureus [gram positive]) by 25 disc diffusion method showed that CHA-S10 and CHA/S had strong antibacterial activity. In 26 conclusion, EW's properties had proven the CHA/S/EW as bone grafts, effectively increasing 27 pore size, porosity, biocompatibility, and strong antibacterial properties. |
| Group of Knowledge | : | Fisika |
| Original Language | : | English |
| Level | : | Internasional |
| Status | : |
Published
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| No | Title | Action |
|---|---|---|
| 1 |
Diana_JBiomaterialScience_2022.pdf
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