ACADSTAFF UGM
| Title | : | Encapsulation of curcumin in chitosan-pectin beads and its release study |
| Author | : |
Drs. Dwi Siswanta, M.Eng., Ph.D. (1) HARIYANTI HUTABARAT (2) |
| Date | : | 0 2017 |
| Keyword | : | beads, chitosan, curcumin, lauric acid, pectin, release study beads, chitosan, curcumin, lauric acid, pectin, release study |
| Abstract | : | Curcumin has been the subject of hundreds of published papers over the past three decades, studying its antioxidant, anti-inflammatory, and anti-cancer properties. Although curcumin has many excellent properties, it is not widely used because of its poor aqueous solubility. Curcumin also faces serious problems like low gastrointestinal absorption, poor bioavailability, and rapid metabolism. In this study curcumin loaded beads to overcome the pharmacokinetic problems and to obtain the full benefits of the drug. Beads were prepared by using chitosan, pectin, lauric acid, and glutaraldehyde. Pectin was added to increase hydrophilic properties of the beads, while glutaraldehyde was added to crosslink the chitosan so that the beads can resist at acidic pH. The effect of pH, curcumin concentration, lauric acid, and solvent to release of curcumin from the beads was studied using UV-Vis spectrophotometer. Surface morphology of the prepared beads has been investigated using SEM and FT-IR spectrum was used to study the interaction between polymers. The result from this study indicated that the use of fatty acids could increase encapsulation efficiency of the curcumin in the beads. The concentration of curcumin, lauric acid, solvent, and pH was found to affect the release rate of curcumin from the beads. Releases kinetic of curcumin from the beads followed Korsmeyer-Peppas model with n value <0.43 that means the release mechanism of curcumin from the beads is diffusion. |
| Group of Knowledge | : | |
| Level | : | Internasional |
| Status | : |
Published
|