ACADSTAFF UGM
| Title | : | ESTIMATING THE EFFECT OF DPT VACCATINATION ON CHILD MORTALITY: DESCRIPTIVE ANALYSIS OF DEMOGRAPHIC AND HEALTH SURVELLANCE DATA IN THE DISTRICT OF PURWOREJO |
| Author | : |
Prof. dr. Siswanto Agus Wilopo, SU, M.Sc, Sc.D (1) |
| Date | : | 2008 |
| Keyword | : | |
| Abstract | : | Background: Recent controversial reports suggest that recipients of one dose of DTP vaccine have highermortality than children who have received no DTP vaccine. Those reports were mainly derived from Africancountries where mortality and malnutrion were higher than Indonesia.Objectives: To describe specific and non-specific effects of DTP vaccination on child mortality age 1-24months under routine vaccination program in Indonesia.Methods: During period of January 1 1995 to August 31, 2001 our longitudinal surveillance data at Purworejodistrict provided information on 5647 children below 24 months of age who received DTP and other vaccinations.The main outcome measure was all-cause mortality. Vaccination status on DTP, BCG, and measles werecollected every 90 days and recorded its time at vaccination. Confounding factors associated with mortalitywere also collected. This first report used descriptive analysis and a survival curve (Kaplan-Meier) to examinethe differential of mortality according to sex of the children and among vaccinated and non-vaccinated childrenwith DTP, BCG, and measles vaccines. The second report will use survival analysis to estimate specific andnon-sprecific effects of DTP by considering time at vaccination and other counfounding factors.Results: There is no sex differential of mortality among children in Purworejo. A probability of dying was lowerin the children vaccinated with DTP vaccine compared with those not vaccinated DTP. Simmilarly, vaccinatedchildren with BCG and measles have lower mortality compared to unvaccinated children. There is strongindication that BCG and measles have stronger protected effects to risk of dying than DTP.Conclusion: The study showed lower mortality among children who received DTP, BCG, and measles vaccinescompared those unvaccinated. There were not enough evidences to change current vaccination policy becauseDTP was not associated with any harmful effect among girls.Keywords: non-specific effects, DTP vaccine–child survival- Kaplan Meier’s Curve |
| Group of Knowledge | : | Lain-Lain |
| Level | : | Nasional |
| Status | : |
Published
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