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Title : EVALUATION OF ANTIHYPERLIPIDEMIC ACTIVITY AND TOTAL FLAVONOID CONTENT OF ARTOCARPUS ALTILIS LEAVES EXTRACTS
Author :

Nita Fajaryanti (1) Prof. Dr. apt. Arief Nurrochmad, M.Si., M.Sc. (2) Prof. Dr.rer.nat. Nanang Fakhrudin, M.Si., Apt. (3)

Date : 0 2016
Keyword : Artocarpus altilis, antihyperlipidemic and total flavonoid Artocarpus altilis, antihyperlipidemic and total flavonoid
Abstract : Hyperlipidemic is a lipid metabolism disorder characterized by high levels of blood cholesterol, triglycerides and LDL and low HDL levels. Hyperlipidemic is one of the most important risk factor in the development of atherosclerosis leading to cardiovascular diseases. Breadfruit (Artocarpus altilis(Parkinson) Fosberg.) is an Indonesian native plant tradi tionally used as a cholesterol-lowering remedy. Breadfruit leaf water extract contains various flavonoid compounds, especially prenylated and geranylated flavonoids. The aim of this study was to investigate the antihyperlipidemiceffect of water, ethanol and ethyl acetate extracts of breadfruit leaf by measuring total cholesterol, triglycerides, LDL and HDL levels in male rats induced by a high-fat diet and propylthiouracil (PTU). We also examined whether the antihyperlipidemic effect correlats with the level of flavonoid.The antihiperlipidemic effect of the extracts was tested in whi te male Wistar rats fed with a high-fat (4 ml/200 g) and 0.01% PTUfor 40 days. As a positive control, simvastatin (1.26 mg/kg) was used.The levels of cholesterol, triglycerides, LDL and HDL was determined using ELISA. The total flavonoid content of water, ethanol and ethyl acetate extracts was measured using spectrophotometry after addition AlCl 3. We found that the water, ethanol and ethyl acetate of breadfruit leaves exhibi ts antihyperlipidemic effect by lowering total cholesterol, triglycerides, and LDL levels and increasing the level of HDL. Compare to the water and ethanol extract, the ethyl acetate extract showed the highest antihyperlipidemic activity. The decreasing of cholesterol, triglycerides, and LDL levels and increasing of HDL level upon the treatment of ethyl acetate extracts have a positive correlation with flavonoid content.
Group of Knowledge : Biologi Farmasi
Original Language : English
Level : Internasional
Status :
Published
Document
No Title Document Type Action
1 12_Editorial - IJPCR.pdf
Document Type : [PAK] Halaman Editorial
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2 12_sampul.pdf
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3 12_daftar isi.pdf
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4 ICPAPS_sukun antihiperlipidemia_ori.pdf
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5 12_International Journal of Pharmaceutical and Clinical Research_2.pdf
Document Type : [PAK] Bukti Korespondensi Penulis
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6 EVALUATION OF ANTIHYPERLIPIDEMIC ACTIVITY AND TOTAL FLAVONOID CONTENT OF ARTOCARPUS ALTILIS LEAVES EXTRACTS.pdf
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