ACADSTAFF UGM

CREATION
Title : Health- related quality of life for multiple myeloma patients with bone metastases in Indonesia: A cross-sectional study
Author :

NUTRISIA AS (1) Prof. Dr. Tri Murti Andayani, Sp.FRS., Apt. (2) Dr. apt. Dwi Endarti, S.F., M.Sc. (3) Dr. dr. Kartika Widayati, SpPD-KHOM (4)
Date : 0 2019
Keyword : HRQoL, multiple myeloma HRQoL, multiple myeloma
Abstract : OBJECTIVE: Multiple myeloma (MM) with bone metastases causes a skeletal-related event (SRE), and decreases health-related quality of life (HRQoL). HRQoL needs to be evaluated for health technology assessment (HTA). Furthermore, HRQoL is calculated as a health state utility and is used in the Markov Model for HTA. Therefore, this study aimed to describe the HRQoL of MM patients with bone metastases, using The EuroQol five-dimension five levels (EQ -5D-5L) in Indonesia. METHODS: a cross-sectional, multicenter study for MM patients with bone metastases (aged over 18 years old) that consulted a physician between November 2018 - May 2019 was conducted. The calculated HRQoL illustrated the health state utility, which was assessed using the EQ-5D-5L questionnaire, with the Indonesian value set. In addition, Mann-Whitney analyses were performed to determine the difference in utility scores at different points within the Durie-Salmon staging system and skeletal condition. RESULTS: in 93 patients who completed the questioner, pain was their major concern with prevalence of over 60% (all levels inclusive). Moreover, the mean utility of patients in stage II and III were 0.735 (SD = 0.205) and 0.383 (SD = 0.555), and those without SRE was 0.753 (SD = 0.213) while patients with SRE was 0.302 (SD = 0.562). Therefore, the lessened values were observed at stage III and SRE condition (p<0.05). CONCLUSION: MM patients with bone metastases have poor HRQoL, with pain as the most frequently reported challenge, which is associated with an advanced stage of MM and SRE event
Group of Knowledge : Farmasi Umum dan Apoteker
Original Language : English
Level : Internasional
Status :
Published
Document
No Title Document Type Action
1 HRQOL Myeloma -Sayuti-APJCP_Volume 20_Issue 10_Pages 3161-3166.pdf
Document Type : [PAK] Full Dokumen
[PAK] Full Dokumen View
2 Health-Related Quality of Life in Early Breast Cancer Patients with Hormone Responsive (1).pdf
Document Type : [PAK] Cek Similarity
[PAK] Cek Similarity View
3 27_ APJCP_Sayuti dkk, 2019.pdf
Document Type : Bukti Published
Bukti Published View
4 EC disertasi Nutrisia .pdf
Document Type : Dokumen Pendukung Karya Ilmiah (Hibah, Publikasi, Penelitian, Pengabdian)
Dokumen Pendukung Karya Ilmiah (Hibah, Publikasi, Penelitian, Pengabdian) View