ACADSTAFF UGM
| Title | : | In vitro hemocompatibility of PVA-alginate ester as a candidate for hemodialysis membrane |
| Author | : |
CHOIRUL AMRI (1) Prof. Drs. Mudasir, M.Eng., Ph.D. (2) Prof. Drs. Dwi Siswanta, M.Eng., Ph.D. (3) Prof. Drs. Roto, M.Eng, Ph.D. (4) |
| Date | : | 13 2015 |
| Keyword | : | Hemodialysis membrane, In vitro hemocompatibility, PVA-alginate ester Hemodialysis membrane, In vitro hemocompatibility, PVA-alginate ester |
| Abstract | : | Alginate based biopolymer with improved physical and chemical properties after esterification using polyvinyl alcohol (PVA) has been studied for possible application as a hemodialysis membrane. The alginic acid to vinyl alcohol molar ratio was predetermined at 0, 0.1, 0.5 and 1. Mechanical strength, hydrophilicity and Ca2+ adsorption of the membrane before and after modification were evaluated. The obtained PVA-alginate (PVA-Alg) ester membrane was also confirmed using FTIR and SEM. It shows that the PVA-Alg membrane tensile strength is higher than that of native alginate. The water contact angle of the membrane was found to be around 33-50°. The Ca2+ adsorption capacity tends to decrease with the increase in molar ratio. Furthermore, the modified PVA-Alg ester membrane achieves better protein adsorption and platelet adhesion than the unmodified one. It also exhibits a dialysis performance of 47.1-50.0% for clearance of urea and 42.2-44.6% for clearance of creatinine, respectively. It is expected that this PVA-Alg ester may challenge cellulose acetate for potential application as hemodialysis membranes. © 2015 Elsevier B.V. |
| Group of Knowledge | : | Kimia |
| Original Language | : | English |
| Level | : | Internasional |
| Status | : |
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| 1 |
1-s2_0-S014181301530026X-main.pdf
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| 2 |
In vitro hemocompatibility of PVA-alginate ester as a candidate for hemodialysis membrane.pdf
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| 3 |
In vitro hemocompatibility of PVA-alginate ester as a candidate for hemodialysis membrane.pdf
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