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Title : Model-based estimation of the impact on rotavirus disease of RV3-BB vaccine administered in a neonatal or infant schedule
Author :

Nicholas Geard (1) Richard Bradhurst (2) Nefel Tellioglu (3) dr. Vicka Oktaria, M.P.H., Ph.D (4) Jodie McVernon (5) Amanda Handley (6) Julie E. Bines (7)
Date : 14 2022
Keyword : Rotavirus,RV3-BB vaccine,neonatal schedule,Indonesia,individual-based model Rotavirus,RV3-BB vaccine,neonatal schedule,Indonesia,individual-based model
Abstract : Rotavirus infection is a common cause of severe diarrheal disease and a major cause of deaths and hospitalizations among young children. Incidence of rotavirus has declined globally with increasing vaccine coverage. However, it remains a significant cause of morbidity and mortality in low-income countries where vaccine access is limited and efficacy is lower. The oral human neonatal vaccine RV3- BB can be safely administered earlier than other vaccines, and recent trials in Indonesia have demon- strated high efficacy. In this study, we use a stochastic individual-based model of rotavirus transmission and disease to estimate the anticipated population-level impact of RV3-BB following delivery according to either an infant (2, 4, 6 months) and neonatal (0, 2, 4 months) schedule. Using our model, which incorporated an age- and household-structured population and estimates of vaccine efficacy derived from trial data, we found both delivery schedules to be effective at reducing infection and disease. We estimated 95–96% reductions in infection and disease in children under 12 months of age when vaccine coverage is 85%. We also estimate high levels of indirect protection from vaccination, including 78% reductions in infection in adults over 17 years of age. Even for lower vaccine coverage of 55%, we estimate reductions of 84% in infection and disease in children under 12 months of age. While open questions remain about the drivers of observed lower efficacy in low-income settings, our model suggests RV3-BB could be effective at reducing infection and preventing disease in young infants at the population level.
Group of Knowledge : Epidemiologi
Original Language : English
Level : Internasional
Status :
Published
Document
No Title Document Type Action
1 [2022] Model based estimation of the impact on rotavirus disease of RV3 BB vaccine administered in a neonatal or infant schedule.pdf
Document Type : Bukti Published
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2 [2022] Turnitin Model-based estimation of the impact on rotavirus disease.pdf
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3 [2022] Model based estimation of the impact on rotavirus disease of RV3 BB vaccine administered in a neonatal or infant schedule.pdf
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