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CREATION
Title : Modified Non-Cultured Cell Spray Induced Epithelization in LAMB3 Mutation Epidermolysis Bullosa
Author :

dr. Suci Widhiati, Sp.KK (1) dr. Shinta Trilaksmi Dewi., Ph.D (2) dr. Yefta (3) Prof. Dr. Med. dr. Retno Danarti, Sp.KK(K). (4) Prof. Dr. dr. Hardyanto, Sp.KK(K). (5) dr. Yulia Eka Irmawati (6) dr. Monika Puspitasari (7) Dr. dr. Niken Trisnowati, M.Sc.Sp.KK (8) Prof. dr. Tri Wibawa, Ph.D., Sp.MK(K) (9) Dra. Dewajani Purnomosari, M.Si., Ph.D. (10) Prof. Dr. dr. Yohanes Widodo Wirohadidjojo, Sp.KK(K). (11)

Date : 14 2022
Keyword : revertant mosaicism, silver-sulfadiazine, plastic wrap, chronic wound, junctional epidermolysis bullosa revertant mosaicism, silver-sulfadiazine, plastic wrap, chronic wound, junctional epidermolysis bullosa
Abstract : Background: Autologous non-cultured cell (ANCC) spray has been used to treat burns, chronic wounds, and vitiligo, but its use in junctional epidermolysis bullosa (JEB) has not been published previously. Chronic wounds in JEB are caused by mutations of laminin 332 (L322), whose function is to attach and act as a glue in the basal membrane. It is proposed that ANCC applications can provide keratinocytes and fibroblasts required to improve epithelization and spontaneously correct revertant keratinocytes in the wound area. Purpose: To develop a modified procedure of ANCC spray and improve epithelization using silver sulfadiazine covered with plastic wrap to treat chronic wounds of JEB. Patients and Methods: Shave excision of the donor site was performed on a 19-year-old girl with JEB. The ANCC spray was prepared and applied to the chronic wound, which was then covered with silver sulfadiazine occluded with plastic wrap. Results: Following the ANCC spray application, epithelization was successfully initiated. Unfortunately, the wounds recurred after four months of follow-up. Conclusion: The modified application method of ANCC spray provides a good alternative to treat chronic wounds in JEB.
Group of Knowledge : Penyakit Kulit dan Kelamin
Original Language : English
Level : Internasional
Status :
Published
Document
No Title Document Type Action
1 Modified Non-Cultured Cell_turnitin.pdf
Document Type : [PAK] Cek Similarity
[PAK] Cek Similarity View
2 Modified Non Cultured Cell Spray.pdf
Document Type : [PAK] Full Dokumen
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3 Modified Non Cultured Cell Spray.pdf
Document Type : [PAK] Bukti Korespondensi Penulis
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