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Title : Monomyristin and Monopalmitin Derivatives: Synthesis and Evaluation as Potential Antibacterial and Antifungal Agents
Author :

Prof. Drs. Jumina, Ph.D. (1) ASMA NURMALA (2) ANGGIT FITRIA (3) Dr. Deni Pranowo, S.Si., M.Si. (4) Prof Dr.dr. Eti Nurwening Sholikhah, M.Kes. (5) YEHEZKIEL STEVEN KURNIAWAN (6) Bambang Kuswandi (7)
Date : 29 2018
Keyword : monomyristin ,monopalmitin,synthesis,antibacterial,antifungal monomyristin ,monopalmitin,synthesis,antibacterial,antifungal
Abstract : In the present work, monoacylglycerol derivatives, i.e., 1-monomyristin, 2-monomyristin, and 2-monopalmitin were successfully prepared from commercially available myristic acid and palmitic acid. The 1-monomyristin compound was prepared through a transesteri?cation reaction between ethyl myristate and 1,2-O-isopropylidene glycerol, which was obtained from the protection of glycerol with acetone, then followed by deprotection using Amberlyst-15. On the other hand, 2-monoacylglycerol derivatives were prepared through enzymatic hydrolysis of triglycerides in the presence of Thermomyces lanuginosa lipase enzymes. The synthesized products were analyzed using fourier transform infrared (FTIR) spectrophotometer, gas or liquid chromatography-mass spectrometer (GC-MS or LC-MS), and proton and carbon nuclear magnetic resonance (1H- and 13C-NMR) spectrometers. It was found that monomyristin showed high antibacterial and antifungal activities, while 2-monopalmitin did not show any activity at all. The 1-monomyristin compound showed higher antibacterial activity against Staphylococcus aureus and Aggregatibacter actinomycetemcomitans and also higher antifungal activity against Candida albicans compared to the positive control. Meanwhile, 2-monomyristin showed high antibacterial activity against Escherichia coli. The effect of the acyl position and carbon chains towards antibacterial and antifungal activities was discussed.
Group of Knowledge : Kimia
Original Language : English
Level : Internasional
Status :
Published
Document
No Title Document Type Action
1 J12_5_2018_Monomyristin and Monopalmitin Derivatives Synthesis and Evaluation_Similarity.pdf
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2 J12_9_2018_Monomyristin and Monopalmitin Derivatives Synthesis and Evaluation_Full_dokumen_1.pdf
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3 molecules-23-03141-1.pdf
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4 Monomyristin and Monopalmitin Derivatives_ Synthesis and Evaluation as Potential Antibacterial and Antifungal Agents.pdf
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