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Title : Norovirus and rotavirus infections in children less than five years of age hospitalized with acute gastroenteritis in Indonesia.
Author :

Prof. Dr. dr. Hera Nirwati, M.Kes., Sp.MK. (1) dr. Nenny Sri Mulyani, Sp.A(K). (4) dr. Abu Tholib, M.Sc., Ph.D., Sp.MK(K). (6) dr. Mohamad Saifudin Hakim, M.Sc, Ph.D. (10)

Date : 0 2019
Keyword : norovirus,rotavirus,diarrhea,children norovirus,rotavirus,diarrhea,children
Abstract : Rotaviruses and noroviruses are the most important viral causes of acute gastroenteritis in children. While previous studies of acute gastroenteritis in Indonesia mainly focused on rotavirus, here, we investigated the burden and epidemiology of norovirus and rotavirus disease. Children less than five years of age hospitalized with acute gastroenteritis were enrolled in this study from January to December 2015 at three participating hospitals. Rotavirus was detected by enzyme immunoassay (EIA), followed by genotyping by reverse transcription PCR (RT-PCR). Norovirus genogroups were determined by TaqMan-based quantitative RT-PCR. Among 406 enrolled children, 75 (18.47%), 223 (54.93%) and 29 (7.14%) cases were positive for norovirus, rotavirus and both viruses (mixed infections), respectively. Most cases clinically presented with fever, diarrhea, vomiting and some degree of dehydration. The majority (n?=?69/75 [92%]) of the noroviruses identified belonged to genogroup II, and several genotypes were identified by sequencing a subset of samples. Among 35 samples tested for rotavirus genotype, the most prevalent genotype was G3P[8] (n?=?30/35 [85.6%]). Our study suggests that the burden of norovirus diseases in Indonesian children should not be underestimated. It also shows the emergence of rotavirus genotype G3P[8] in Indonesia.
Group of Knowledge : Mikrobiologi Klinik
Original Language : English
Level : Internasional
Status :
Published
Document
No Title Document Type Action
1 Nirwati2019_Article_NorovirusAndRotavirusInfection.pdf
Document Type : [PAK] Full Dokumen
[PAK] Full Dokumen View
2 Grant Hera Nirwati untuk publikasi Norovirus di Archieve of Virology .pdf
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3 Grant M S Hakim untuk publikasi Norovirus di Archieve of Virology.pdf
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4 CS_Norovirus and rotavirus infections in children less than five years of age hospitalized with acute gastroenteritis in Indonesia.pdf
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5 9_Norovirus and rotavirus infections in children less than five years of age hospitalized with acute gastroenteritis in Indonesia.pdf
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6 Hasil similarity-Norovirus and rotavirus infections in children.pdf
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7 PEER REVIEW_Abu Tholib 9.pdf
Document Type : [PAK] Peer Review
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8 PEER REVIEW_Abu Tholib 9.pdf
Document Type : [PAK] Peer Review
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