ACADSTAFF UGM
| Title | : | ONE-POT SYNTHESIS, ANTIOXIDANT ACTIVITY AND TOXICITY EVALUATION OF SOME HYDROXYXANTHONES |
| Author | : |
Emmy Yuanita (1) Harno Dwi Pranowo (2) Drs. Dwi Siswanta, M.Eng., Ph.D. (3) Respati Tri Swasono, S.Si., M.Phil., Ph.D (4) Prof. Dr. Mustofa, Apt., M.Kes. (5) Dr. apt. Abdul Karim Zulkarnain, M.Si.,SE. (6) Prof. Dr. Jumina (7) |
| Date | : | 0 2012 |
| Keyword | : | antioxidant, hydroxyxanthones, 2,2-diphenyl- 1-picrylhydrazyl assay, Eaton’s reagent antioxidant, hydroxyxanthones, 2,2-diphenyl- 1-picrylhydrazyl assay, Eaton’s reagent |
| Abstract | : | Some new hydroxyxanthone compounds were prepared through one pot cyclodehydration reaction of hydroxybenzoic acid derivatives (salicylic acid or resorcylic acid) with phloroglucinol or pyrogallol in the presence of Eaton’s reagent (P2O5/MeSO3H). The synthesized compounds were screened for their antioxidant activities by 2,2-diphenyl-1-picrylhydrazyl (DPPH) methods to determine their inhibitory concentration (IC50). Cytotoxicity of the prepared compounds was also evaluated by MMT assay on Vero cell line. It was observed that the position and the number of hydroxyl groups could significantly affect the potent antioxidant activity of the prepared compounds. Cytotoxicity evaluation of new compounds indicated that the synthesized series of hydroxyl xanthone were categorized as very strong antioxidants and showed potential development as a commercial antioxidant compound. |
| Group of Knowledge | : | Farmasetika dan Teknologi Farmasi |
| Original Language | : | English |
| Level | : | Internasional |
| Status | : |
Published
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ONE-POT SYNTHESIS, ANTIOXIDANT ACTIVITY AND TOXICITY EVALUATION OF SOME HYDROXYXANTHONES.pdf
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