ACADSTAFF UGM
| Title | : | Optimization of Gelling Agent and Sunscreen Activity Test on 4-OH- chalcone Gel Using In Vitro Method |
| Author | : |
Prof. Dr. Drs. Abdul Karim Zulkarnain, M.Si., Apt. (1) Prof. Dr. Jumina (2) GALIH TITISARI KHARISMAWATI (3) FINA ANJANI LARASATI (4) |
| Date | : | 24 2023 |
| Keyword | : | 4-OH-chalcone, SLD, SPF 4-OH-chalcone, SLD, SPF |
| Abstract | : | 4-OH-chalcone is suspected of absorbing and reducing ultraviolet radiation intensity exposed to the skin. It was formulated in gel dosage form using a combination of 0.50-1.00% w/w carbopol content, 19-20% w/w propylene glycol content, and 0.50-1.00% w/w CMC-Na content. This study aimed to optimize the three gel bases and evaluate the physical properties, physical stability, and activity of 4-OH-chalcone gel as a sunscreen using in vitro method. Simplex Lattice Design (SLD) method was used to optimize the gel base using Design Expert software version 10.0. The activity of 4-OH- chalcone gel as sunscreen was determined spectrophotometrically by determining the Sun Protecting Factor (SPF) value, percent transmission of erythema (% TE), and percent transmission of pigmentation (% TP). Data were analyzed statistically using SPSS Statistical software. The optimum formula of 4-OH-chalcone gel was 0.50% w/w carbopol content, 0.50% w/w carboxymethylcellulose sodium content, and 20.0% w/w propylene glycol content which had a pH of 5.59, viscosity of 37.4 dPa.s, spreadability of 28.8 cm2, adhesive time of 1.28 seconds, SPF value of 28.65, %, TE value of 16.44%, %TP value of 0.24%, and relatively stable physical properties. |
| Group of Knowledge | : | Farmasetika dan Teknologi Farmasi |
| Original Language | : | English |
| Level | : | Internasional |
| Status | : |
Published
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| No | Title | Action |
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| 1 |
2023 IJP KARIM JUMINA GALIH DAN FINAdocument.pdf
Document Type : [PAK] Full Dokumen
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| 2 |
Optimization of Gelling Agent and Sunscreen Activity Test on 4-OHchalcone Gel Using In Vitro Method.pdf
Document Type : [PAK] Cek Similarity
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| 3 |
koresponden karim optimization FIXX.pdf
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