ACADSTAFF UGM
| Title | : | Protection by Ethanolic Extract from Ulva lactuca L. against Acutr Myocardial Infarction: Antioxidant and Antiapoptotic Activities |
| Author | : |
WAHYU WIDYANINGSIH (1) Drs. Zulaela, Dipl.Med.Stats.,M.Si (3) Prof. Dr. apt. Sugiyanto, SU. (4) drh. Sitarina Widyarini, M.P., Ph.D. (5) |
| Date | : | 0 2017 |
| Keyword | : | Ulva lactuca,isoproterenol,antioxidant,apoptosis,melatonin Ulva lactuca,isoproterenol,antioxidant,apoptosis,melatonin |
| Abstract | : | Reactive oxygen species (ROS) play a major role in myocardial damage during acute myocardial infarction (AMI). This study aimed to determine the antioxidant antiapoptotic activities of an ethanolic extract from Ulva lactuca (EEUL) against AMI. Thirty-six male Wistar rats were devided into six groups: one control group and five treatment group. Treatment group II was givwn 85 mg/kg B>W> of isoproterenol (ISO), group III, IV, and V were given 85 mg/kg B.W. ISO and EEUL at 250, 500, and 750 mg/kg B.W., respectively. Group VI was given 10 mg kg/B.W. and melatonin. Melatonin and EEUL were orally administered for 28 days. ISO was injected inptraperitonially at day 29 and 30 to induce AMI. On day 31, blood was collected for antioxidant assay and heart tissues were xollected for histological examination. The activity of catalase (CAT), an endogenous antioxidant, in the EEUL-treatment groups were significantly increased compared to that of the ISO-treatment group (p < 0.001). The EEUL-treatment groups showed significantly decreased expression of caspase-3 (p < 0.001) and better myocardial tissue morphology. EEUL protects against AMI possibly because of its antioxidant and antiapoptotic properties |
| Group of Knowledge | : | Farmakologi dan Farmasi Klinik |
| Original Language | : | English |
| Level | : | Internasional |
| Status | : |
Published
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