ACADSTAFF UGM

CREATION
Title : Resistance Profile of Extended Spectrum Beta Lactamase-Producing Escherichia coli Bacteria using Vitek® 2 Compact Method
Author :

Freshinta Jellia Wibisono (1) Prof. Dr. drh. Bambang Sumiarto Moecharom, S.U., M.Sc. (2) Prof. Dr. drh. Tri Untari, M.Si. (3) MUSTOFA HELMI EFFENDI4 (4) DIAN AYU PERMATASARI5 (5) ADIANA MUTAMSARI WITANINGRUM (6)
Date : 15 2020
Keyword : ESBL-producing Escherichia coli, Multidrug resistance, Vitek® 2 Compact Method ESBL-producing Escherichia coli, Multidrug resistance, Vitek® 2 Compact Method
Abstract : This study aimed to determine the resistance profile and the nature of multidrug resistance in Extended Spectrum Beta Lactamase (ESBL)-producing Escherichia coli (E.coli) against several classes of antibiotics. Positive isolates of ESBL-producing E.coli were tested for antibiotic sensitivity using the VITEK® 2 compact method which then analyzed automatically. The results showed an antibiotic resistance profile against ESBL-producing E.coli showed the highest level of antibiotics in beta lactam, amoxicillin, ampicillin, cefazolin, cefotaxime, and ceftriaxone at 100%. Subsequent results found a relatively high level of resistance in the antibiotics aztreonam (86.36%), trimethoprim/sulfamethoxazole (77.27%), gentamicin (72.73%), and ciprofloxacin (68.18%). Antibiotics from carbapenem groups such as ertapenem and memenem, and antibiotics from the aminoglycosides (amicasin) and tigecycline groups of tetracycline still showed a high sensitivity level of 100%. The most common resistance patterns found in ESBL-producing E.coli isolates are AM/AMP/KZ/CTX/CRO/ATM/GM/CIP as much as 22.73%, and AM/AMP/KZ/CTX/CRO/ATM/GM/CIP/SXT patterns of 18.2%. The results of multi-class antibiotic resistance showed that 86.36% had multidrug resistance. The highest multidrug resistance pattern in ESBL-producing E.coli occurred with a BL/AG/Q/SP pattern of 50%. Other patterns of multidrug resistance in ESBL-producing E.coli that can be found in this study are, the BL/AG/Q/SP pattern is 18.20%, the BL/AG/Q/SP pattern is 13.64%, and the BL/AG/Q pattern is 4.55%. The high profile of resistance and the nature of multidrug resistance in ESBL-producing E.coli has the potential to spread these resistant genes, thus risking the use of antibiotics as a public health therapy and animal health, therefore further evaluation and control are needed.
Group of Knowledge : Sain Veteriner
Original Language : Bahasa Indonesia
Level : Nasional
Status :
Published
Document
No Title Document Type Action
1 sertifikat buletin peternakan.pdf
Document Type : Dokumen Pendukung Karya Ilmiah (Hibah, Publikasi, Penelitian, Pengabdian)
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2 cover-vtex.pdf
Document Type : [PAK] Halaman Cover
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3 editorial.pdf
Document Type : [PAK] Halaman Editorial
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4 Full dok Vtex.pdf
Document Type : [PAK] Full Dokumen
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5 conten Vtex.pdf
Document Type : [PAK] Daftar Isi
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6 Artikel Vtex.pdf
Document Type : Dokumen Pendukung Karya Ilmiah (Hibah, Publikasi, Penelitian, Pengabdian)
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