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CREATION
Title : Revealing Chemopreventive Potential of Active Constituents from Medicinal Herbs Used in Indonesia for (Metastatic) Breast Cancer with Particular Molecular Targets
Author :

Puguh Indrasetiawan, S.Farm., M.Sc., Ph.D., Apt. (1) Sari Haryanti (2) Prof. Dr. apt. Edy Meiyanto, M.Si. (3)
Date : 0 2020
Keyword : Indonesian medicinal herbs, Breast cancer, Active constituents, Molecular targets Indonesian medicinal herbs, Breast cancer, Active constituents, Molecular targets
Abstract : Breast cancer remains one of the highest causes of cancer-related deaths in the world, including Indonesia. In spite of following the standard protocol therapy, patients in developing countries consume medicinal herbs as an alternative, complementary, as well as supportive therapies. Several herbs have been recognized to be used for this purpose. Annona muricata, Curcuma longa, Curcuma xanthorrhiza, Curcuma zedoaria, Phyllanthus urinaria, Gynura procumbens, Garcinia mangostana, Morinda citrifolia, and Nigella sativa are some of the plants used as chemopreventive agents with several formula. Curcumin, obtained from C. longa and C. xanthorrhiza, acts as p53 regulator and pro-oxidant in MCF-7 cells and also acts as a fatty acid synthase inhibitor in MDA-MB-231 cells. Xanthorrhizol from C. xanthorrhiza has pro-apoptotic activity via modulation of breast cancerl-2, p53, and PARP-1 protein levels. Another Curcuma, C. zedoaria, contains curcumenone, curcumenol and curdion, which show pro-apoptotic activity in various cell lines and a cancer-induced mouse model. Corilagin and geraniin from P. urinaria have different pro-apoptotic effects, in which, the corilagin-caused apoptotic effect is mediated by extrinsic and mitochondrial pathways, whereas geraniin induces apoptosis via ROS-mediated stimulation, both in MCF-7 cells. Thymoquinone from N. sativa has been extensively studied for its anticancer activities in recent years, whereas various types of extracts of A. muricata show anticancer activities in vitro and in vivo. As for real-life applications, plants are cultivated, collected and mixed depending on the use as herbal medicines. Active compounds might be formulated if deemed possible. Not only those, but the development of more potential derivatives is also necessary to produce more optimum anti-cancer agents. In conclusion, Indonesian plants and their active constituents show potential activity to be developed as chemopreventive agents.
Group of Knowledge : Biologi Farmasi
Original Language : English
Level : Nasional
Status :
Published
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No Title Document Type Action
1 337-1325-1-PB.pdf
Document Type : Bukti Accepted
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2 FULL DOKUMEN PUBLIKASI IJCC NOV 2020.pdf
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3 IJCC 2020 NOV SINTA.pdf
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4 Revealing Chemopreventive Potential of Active Constituents from Medicinal Herbs Used in Indonesia for Breast Cancer with Particular Molecular Targets-2.pdf
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5 BUKTI KORESPONDENSI.pdf
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