ACADSTAFF UGM

CREATION
Title : Screening test for COVID-19 in outpatient settings: a rapid review
Author :

dr. Antonia Morita Iswari Saktiawati., Ph.D (1) TAUFIK MULYA PERDANA (2) dr. Vicka Oktaria, M.P.H., Ph.D (3) Prof. dr. Indah Kartika Murni, M.Kes., Sp.A(K)., Ph.D. (4) dr. Elizabeth Henny Herningtyas, M.Si., Ph.D. SpPK(K) (5)
Date : 20 2021
Keyword : Screening, diagnosis, COVID-19, sensitivity, specificity, accuracy SARS-CoV-2 Screening, diagnosis, COVID-19, sensitivity, specificity, accuracy SARS-CoV-2
Abstract : Background The screening for SARS-CoV-2 during this pandemic is crucial to limit the virus's spread by identifying and contact tracing of individuals with or without symptoms suggesting COVID-19 to reduce further disease transmission. The evidence-based best-performed screening test for COVID-19 needs to be identified. Methods To estimate the screening test accuracy against RT-PCR for COVID-19, we screened multiple databases until December 2, 2020. Findings We included seven studies with 1536 subjects in the analysis. Serological assay studies' pooled sensitivity and specificity were 10% (95% CI: 7-13) and 92% (95% CI: 89-96), respectively, and no heterogeneity was found. The pooled PPV of serological assays studies was 70% (95% CI:60-80) and pooled NPV was 56% (95% CI:52-60). The pooled diagnostic accuracy of other tests (clinical symptoms, antigen test, chest CT-scan) cannot be determined as only a few studies available. The sensitivity and specificity of other tests ranged from 0% to 100% and 21.3% to 100%, respectively. The strength of evidence within all seven studies was low to moderate. Interpretation The medium evidence of these studies shows that serology assay is not accurate for COVID-19 screening. Once other screening tests have real-life implementation data, the pooled diagnostic accuracy can be determined.
Group of Knowledge : Ilmu Kedokteran Klinik
Original Language : English
Level : Internasional
Status :
Draft
Document
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