ACADSTAFF UGM
| Title | : | Synthesis and Antiplasmodial Activity Testing of(1)-N-(4-Methoxybenzyl)-1,10-Phenanthrolinium Bromide |
| Author | : |
Prof. Dr. Sabirin Matsyeh (1) Prof. Dr. Mustofa, Apt., M.Kes. (2) Dr. dr. Mahardika Agus Wijayanti, DTM&H., M.Kes. (3) Prof Dr.dr. Eti Nurwening Sholikhah, M.Kes. (5) |
| Date | : | 2007 |
| Keyword | : | (1)-N-(4-METHOXYBENZYL)-1-10-PHENANTHROLINIUM BROMIDE COMP,ANTIPLASMODIAL ACTIVITY,IC50 (1)-N-(4-METHOXYBENZYL)-1-10-PHENANTHROLINIUM BROMIDE COMP,ANTIPLASMODIAL ACTIVITY,IC50 |
| Abstract | : | Synthesis of (1)-N-(4-methoxybenzyl)-1,10-phenanthroline bromide from 1,10-phenanthroline monohydrate and 4-methoxybenzaldehyde as starting material and evaluation of its antiplasmodial activities have been carried out. The 4-methoxybenzyl alcohol compound was prepared from 4-methoxy-benzaldehyde using sodium borohydride (NaBH4) reagent and ethanol absolute solution. The mixture was refluxed for 3 h. Then it yielded colorless dilution compound with 90.41% in efficiency. Furthermore, bromination of 4-methoxybenzyl alcohol with phosphorus bromide (PBr3) was conducted by refluxing for 3 h. The product of this reaction was yellow liquid of 4-methoxybenzyl bromide, 79.03% yield and 95.34% purity. The final step of reaction was benzylation of 1,10-phenanthroline monohydrate with 4-methoxybenzyl bromide reagent. It was conducted by refluxing in aceton for 8 h at 55oC. The yield of the reaction was (1)-N-(4-methoxybenzyl)-1,10-phenanthroline bromide (77.63%). It is pink solid form, and its melting point is 192-193oC. Identification of the product was carried out by means of GC-MS, IR and 1H-NMR spectrometers. The in vitro antiplasmodial activity on chloroquine-resistant Plasmodium falciparum FCR-3 strain and chloroquine sensitive P. falciparum D10 strain for (1)-N-(4-methoxybenzyl)-1,10-phenanthroline bromide were determined by microscopic method. The result showed that after 72 h incubation, it has IC50 0.93&plus mn |
| Group of Knowledge | : | Ilmu Kedokteran Dasar & Biomedis |
| Original Language | : | English |
| Level | : | Nasional |
| Status | : |
Published
|
| No | Title | Action |
|---|