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CREATION
Title : Synthesis N-Phenyl Pyrazoline from Dibenzalacetone and Heme Polymeration Inhibitory Activity (HPIA) Assay
Author :

LINDA EKAWATI (1) Prof. Drs. Bambang Purwono, M.Sc., Ph.D. (2) Dr. Muhammad Idham Darussalam Mardjan S.Si., M.Sc. (3)
Date : 24 2020
Keyword : Dibenzalacetone, HPIA, N-phenyl pyrazoline Dibenzalacetone, HPIA, N-phenyl pyrazoline
Abstract : The synthesis of 1,5-diphenyl-3-styryl-4,5-dihydro-1H-pyrazole (B1) and 5-(3,4-diimethoxyphenyl)-3-(3,4-dimethoxystyryl)-1-phenyl-4,5-dihydro-1H-pyrazole (B2) have been conducted from 1,5-diphenylpenta-1,4-dien-3-on (A1) and 1,5-bis(3,4-dimethoxyphenyl)penta-1,4-dien-3-one (A2). Heme polymerization inhibitory activity (HPIA) assay of the synthesized compounds has also been carried out. The first step of reaction was Claisen-Schmidt condensation of benzaldehyde derivatives and acetone using NaOH 20% and ethanol as solvent. Dibenzalacetone derivatives were reacted with phenylhydrazine using acetic acid to form N-phenylpyrazoline. The structure of products was characterized by FT-IR, GC-MS, DI-MS, 1H- and 13C-NMR The result of heme polymerization inhibitory activity assay showed that IC50 of B1 and B2 1.26 and 0.79 mM while quinine 1.26 mM. The result indicated that compound B2 was more potent as antimalarial than quinine.
Group of Knowledge :
Level : Internasional
Status :
Published
Document
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1 2020_Similarity_Key Eng Mat_Synthesis N-Phenyl Pyrazoline from Dibenzalacetone.pdf
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2 2020_Daftar Isi_Key Eng Mat_Synthesis N-Phenyl Pyrazoline from Dibenzalacetone.pdf
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3 2020_Daftar Committee_ Editor_Peserta_Key Eng Mat_Synthesis N-Phenyl Pyrazoline from Dibenzalacetone.pdf
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4 2023_Genap_Surat Pernyataan Keabsahan Karya Ilmiah_M_ Idham D_ M_.pdf
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5 2023_Genap_Surat Pernyataan Keabsahan Karya Ilmiah_M_ Idham D_ M__update.pdf
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6 Synthesis N-Phenyl Pyrazoline from Dibenzalacetone_Update.pdf
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7 Synthesis N-Phenyl Pyrazoline from Dibenzalacetone and Heme Polymeration Inhibitory Activity (HPIA) Assay (3) (1).pdf
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8 Synthesis N-phenyl pyrazoline from dibenzalacetone and heme.pdf
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