ACADSTAFF UGM
| Title | : | Synthesis of a potential angiogenesis inhibitor compound: 2-benzylidene cyclohexane-1,3-dione |
| Author | : |
Enade Perdana Istyastono (1) Dr. apt. Nunung Yuniarti, S.F., M.Si. (2) Prof. Drs. Jumina, Ph.D. (3) |
| Date | : | 0 2009 |
| Keyword | : | synthesis,angiogenesis inhibitor,2-benzylidene-cyclohexane-1,3-dione synthesis,angiogenesis inhibitor,2-benzylidene-cyclohexane-1,3-dione |
| Abstract | : | Synthesis of an aromatic cyclic enadione, 2-benzylidene-cyclohexane-1,3-dione (a potential angiogenesis inhibitor), has been done using benzaldehide (50 mmole) and cyclohexane-1,3-dione (50 mmole) as starting materials and NaOH 1.0 N as a catalyst. Odorless and white needle-shape powder has been achieved. The powder was 252.7 mg (2.53 %) and the purity of the powder was 88.81 %. Its melting point was 214.8 oC. The purity of the product was examined by gas chromatography, while the structure elucidation was done using IR spectrometer, 1H-NMR spectrometer, and GC-MS. IR spectrometer showed that the compound had a -C=O bond conjugated to an alkene or a phenyl moiety, methylen groups, and alkene’s -C–H bonds. 1H-NMR spectrometer showed that the compound had benzene moiety and methylen moieties, which were in alpha and beta position to a carbonyl group. GC-MS showed that the molecular weight of the compound was 200 atomic mass unit. |
| Group of Knowledge | : | Farmakologi dan Farmasi Klinik |
| Original Language | : | English |
| Level | : | Nasional |
| Status | : |
Published
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