ACADSTAFF UGM
| Title | : | Synthesis of Chalcone Derivatives and Their in vitro Anticancer Test against Breast (T47D) and Colon (WiDr) Cancer Cell Line |
| Author | : |
Prof. Dr. Chairil Anwar (1) YOGO DWI PRASETYO (2) Prof. Dr. Sabirin Matsyeh (3) Dr. Winarto Haryadi, M.Si. (4) Prof Dr.dr. Eti Nurwening Sholikhah, M.Kes. (5) NENDROWATI (6) |
| Date | : | 2018 |
| Keyword | : | chalcone derivatives,anticancer,breast cancer,colon cancer chalcone derivatives,anticancer,breast cancer,colon cancer |
| Abstract | : | The synthesis of chalcone derivatives as target compounds and anticancer test against breast (T47D) andcolon (WiDr) cell line had been performed. The synthesis was performed by Claisen-Schmidt condensation by usingacetophenone and benzaldehyde derivatives. The anticancer activity test of chalcone derivatives was carried out byMTT assay against T47D and WiDr cell lines. The synthesis was started by reacting 4-hydroxyacetophenone andbenzaldehyde derivatives such asp-anisaldehyde (chalcone1[(E)-4'-hydroxy-4-methoxychalcone]), veratraldehyde(chalcone2[(E)-4'-hydroxy-3,4-dimethoxychalcone]), 4-chlorobenzaldehyde (chalcone3[(E)-4'-hydroxy-4-chlorochalcone]) and 2,4-dihydroxyacetophenone with 4-chlorobenzaldehyde (chalcone4[(E)-2',4'-dihydroxy-4-chlorochalcone]) in methanol as solvent. The synthesis was carried out in alkaline condition (KOH) by stirring themixture at room temperature for 48 h. The structures of products were identified by FTIR, GC-MS,1H- and13C-NMRspectrometers. The results showed that the chalcone derivatives (1-4) were yielded in 96; 97; 96; and 93%,respectively as yellow solid. The anticancer test indicated that the chalcone4was the most active towards T47D cellline with IC50of42.66?g/mLandthechalcone3was the most active against WiDr cell line with IC50of20.42?g/mL. |
| Group of Knowledge | : | Kimia |
| Original Language | : | English |
| Level | : | Internasional |
| Status | : |
Published
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