ACADSTAFF UGM
| Title | : | The Effect of Freeze-Thaw Treatment to the Properties of Gelatin-Carbonated Hydroxypatite Membrane for Nerve Regeneration Scaffold |
| Author | : |
ARUM PATRIATI (1) Dr. drg. Retno Ardhani, M.Sc. (2) Prof. Dr.rer.nat. Harno Dwi Pranowo, M.Si. (3) Edy Giri Rachman (4) Prof. drg. Ika Dewi Ana, M.Kes., Ph.D. (5) |
| Date | : | 0 2016 |
| Keyword | : | gelatin, carbonated hydroxy apatite, freeze-thaw, nerve regeneration. gelatin, carbonated hydroxy apatite, freeze-thaw, nerve regeneration. |
| Abstract | : | One of the major challenges in the development of scaffold for nerve regeneration is enhancing mechanical strength of the material to avoid the scaffold to rapidly degrade during regeneration process in nerve system. The aim of this study was to reveal the effect of freeze-thaw to the properties of gelatin-carbonated hydroxy apatite (CHA) membrane in two ratios 7 to 3 and 6 to 4 for gelatin to CHA respectively. Some variations of freeze-thaw cycles were applied for both ratios, which is referred for its biocompatibility in cells. The CHA was synthesized by wet precipitating method of calcium hydroxide and phosphoric acid in gelatin solution at room temperature and open system. The X-Ray Diffraction (XRD) and FTIR analysis was conducted to confirm the formation of type-B CHA in gelatin matrix. The resulted membrane was then subject for membrane characterization. It was known from the study that freeze-thaw treatment during membrane fabrication affects several properties of the membrane. Platelet loading capability decreased when freeze-thaw cycles increased. Meanwhile, the platelet was released more rapidly by freeze-thawed gelatin-CHA membrane compared to non-freeze-thawed one. The degradation percentage of the membrane decreased with the increasing freeze-thaw cycles, showing 4 hours slower degradation in the freezethawed membrane compared to the unfreeze-thawed one. Furthermore, it was observed that freeze-thaw improved the tensile strength of the membrane and the modulus elasticity increased simultaneously. Moreover, in general it was observed from this study that freeze-thaw treatment did not affect permeability of the membranes towards glucose transport. |
| Group of Knowledge | : | Lain-Lain |
| Original Language | : | English |
| Level | : | Internasional |
| Status | : |
Published
|
| No | Title | Action |
|---|---|---|
| 1 |
32_ 2016-KEM-A Patriati.pdf
Document Type : [PAK] Full Dokumen
|
View |
| 2 |
Akreditasi Key Engineering Materials.pdf
Document Type :
|
View |
| 3 |
13_ Similaritas The Effect of Freeze-Thaw Treatment to the Properties of Gelatin-Carbonated Hydroxypatite Membrane for Nerve Regeneration Scaffold.pdf
Document Type : [PAK] Cek Similarity
|
View |
| 4 |
Bukti KorespondensiKEM Metronidazole - 2016.pdf
Document Type : [PAK] Bukti Korespondensi Penulis
|
View |