ACADSTAFF UGM
| Title | : | The role of insulin receptor substrate 1 gene polymorphism Gly972Arg as a risk factor for ischemic stroke among Indonesian subjects |
| Author | : |
Syahrul (1) Prof. Dr. dr. Samekto Wibowo, Sp.S(K)., Sp.S(K). (2) Prof. dr. Sofia Mubarika Harjana, M.Med.Sc., Ph.D. (3) Dr. Med. dr. Indwiani Astuti (4) Fariz Nurwidya (5) |
| Date | : | 2018 |
| Keyword | : | IRS-1 gene polymorphism Gly972Arg; Insulin resistance; Ischemic stroke; Metabolic syndrome IRS-1 gene polymorphism Gly972Arg; Insulin resistance; Ischemic stroke; Metabolic syndrome |
| Abstract | : | OBJECTIVE:The identification of new genetic-associated risk factor of ischemic stroke could improves strategies for stroke prevention. This study aims to identify insulin receptor substrate 1 (IRS-1) gene polymorphism Gly972Arg as the risk factor for ischemic stroke among Indonesian subjects. The case-control study was conducted by matching the gender and race on 85 cases of patients with ischemic stroke and 86 healthy non-stroke control subjects. Ischemic stroke was established by the complete neurology examination and brain computed tomography scan or magnetic resonance imaging. Polymerase chain reaction-Restriction Fragment Length Polymorphism was performed to analyze IRS-1 gene Gly972Arg genotype. RESULTS:There were 85 ischemic stroke cases and 86 control subjects. The distribution of nucleotide IRS-1 gene polymorphism Gly972Arg in the ischemic stroke vs health controls for GG were 32.2% vs 41.5%, for GR were 16% vs 7.6%, and for RR were 0.5% vs 1.9%. IRS-1 gene polymorphism Gly972Arg was found as significant risk factor for ischemic stroke [odds ratio of 2.6 (1.27-5.27); CI 95%, p?=?0.008]. Conclusively, the IRS-1 gene polymorphism Gly972Arg should be considered as an important factor in the prevention and treatment of ischemic stroke. |
| Group of Knowledge | : | Penyakit Syaraf |
| Original Language | : | English |
| Level | : | Internasional |
| Status | : |
Published
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| 1 |
The role of insulin receptor substrate 1 gene polymorphism Gly972Arg .pdf
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| 2 |
The role of insulin receptor substrate 1 gene polymorphism Gly972Arg as a risk factor for ischemic stroke among Indonesian subjects.pdf
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